Symbol
Name
ID

Mir146
microRNA 146
MGI:2676831

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

enlarged spleen

increased spleen weight

abnormal lymphopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

anemia

abnormal bone marrow cell morphology/development

increased bone marrow cell number

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

thrombocytopenia

increased germinal center B cell number

increased plasma cell number

increased T follicular helper cell number

increased regulatory T cell number

decreased lymphocyte cell number

decreased monocyte cell number

decreased leukocyte cell number

abnormal spleen B cell follicle morphology

increased spleen germinal center number

increased spleen germinal center size

increased IgG1 level

increased IgG level

abnormal T cell activation

abnormal regulatory T cell physiology

abnormal macrophage physiology

increased macrophage nitric oxide production

abnormal bone marrow cell physiology

Availability

Mouse Genotype

Mir146^tm1.1Bal/Mir146^tm1.1Bal

Mir146^tm2.1Bal/Mir146^tm2.1Bal

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Tg(Cr2-cre)3Cgn/0 (conditional)

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Ighg1^tm1(cre)Cgn/Ighg1⁺ (conditional)

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Tg(CD2-icre)4Kio/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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